SD-OCT and autofluorescence characteristics of autoimmune retinopathy
Identifieur interne : 001128 ( Main/Exploration ); précédent : 001127; suivant : 001129SD-OCT and autofluorescence characteristics of autoimmune retinopathy
Auteurs : Kathryn Lynn Pepple [États-Unis] ; Michael Cusick [États-Unis] ; Glenn J. Jaffe [États-Unis] ; Prithvi Mruthyunjaya [États-Unis]Source :
- British Journal of Ophthalmology [ 0007-1161 ] ; 2013-02.
English descriptors
- Teeft :
- Abnormality, Acute cases, Antirecoverin antibody, Antiretinal, Antiretinal antibodies, Attenuated, Attenuated vessels, Autoantibody, Autoimmune, Autoimmune retinopathy, Bipolar cells, Bronchogenic lung, Bronchogenic lung cancer, Central island, Central region, Clinical science, Coherence, Coherence tomograms, Coherence tomography, Coherence tomography imaging, Colour, Colour fundus, Colour fundus photographs, Colour imaging, Complex junction, Cone response, Cone responses, Diagnostic criteria, Duke university, Epiretinal membrane, Exam, Family history, Fovea, Fundus, Generalised, Imaging, Imaging abnormalities, Imaging modalities, Imaging technologies, Inner border, Inner boundary, Inner ring, Macular hole, Melanoma, Metastatic melanoma, Moderate cone dysfunction, Ndings, Ophthalmol, Ophthalmoscopic examination, Optic nerve pallor, Outer plexiform, Patient serum, Pepple, Peripheral border, Physical exam, Progressive loss, Retinal, Retinal architecture, Retinal degeneration, Retinal pigment epithelial, Retinitis pigmentosa, Retinopathy, Retinopathy patient, Spectral domain, Subacute vision loss, Tentative diagnosis, Vascular attenuation, Vision loss, Visual acuity, Vitreous opacity, Western blot, White bars.
Abstract
Aims To report abnormal fundus hyperautofluorescence (hyper-AF) and loss of outer retinal layers by spectral domain optical coherence tomography in patients with autoimmune retinopathy (AIR). Methods Retrospective, observational case series of 14 eyes of 7 patients diagnosed with an AIR for whom colour fundus photographs, fundus AF images and spectral domain optical coherence tomograms (SD-OCT) were obtained at presentation. Results Seven patients were identified ranging in age from 24 to 73 years. Six had a history of cancer and were diagnosed with cancer associated retinopathy or melanoma associated retinopathy. Among the seven patients, six (86%) had abnormalities by AF or SD-OCT including loss of outer retinal layers in association with hyper-AF. One patient with melanoma associated retinopathy did not have any imaging abnormalities. In one patient with cancer associated retinopathy followed over 8 months, progressive loss of retinal architecture was associated with the formation of a hyper-AF ring. Conclusions Patients with AIR can present with structural abnormalities that are detectable by fundus AF and SD-OCT. The areas of hyper-AF correspond to loss of outer-retinal structures such as the inner segment/outer segment junction, the external limiting membrane and outer nuclear layer. These imaging modalities may be useful in establishing the diagnosis of this rare disease, monitoring disease progression and evaluating response to therapy.
Url:
DOI: 10.1136/bjophthalmol-2012-302524
Affiliations:
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<term>Antiretinal antibodies</term>
<term>Attenuated</term>
<term>Attenuated vessels</term>
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<term>Autoimmune</term>
<term>Autoimmune retinopathy</term>
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<term>Bronchogenic lung cancer</term>
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<term>Coherence tomography imaging</term>
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<term>Colour fundus photographs</term>
<term>Colour imaging</term>
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<term>Duke university</term>
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<term>Family history</term>
<term>Fovea</term>
<term>Fundus</term>
<term>Generalised</term>
<term>Imaging</term>
<term>Imaging abnormalities</term>
<term>Imaging modalities</term>
<term>Imaging technologies</term>
<term>Inner border</term>
<term>Inner boundary</term>
<term>Inner ring</term>
<term>Macular hole</term>
<term>Melanoma</term>
<term>Metastatic melanoma</term>
<term>Moderate cone dysfunction</term>
<term>Ndings</term>
<term>Ophthalmol</term>
<term>Ophthalmoscopic examination</term>
<term>Optic nerve pallor</term>
<term>Outer plexiform</term>
<term>Patient serum</term>
<term>Pepple</term>
<term>Peripheral border</term>
<term>Physical exam</term>
<term>Progressive loss</term>
<term>Retinal</term>
<term>Retinal architecture</term>
<term>Retinal degeneration</term>
<term>Retinal pigment epithelial</term>
<term>Retinitis pigmentosa</term>
<term>Retinopathy</term>
<term>Retinopathy patient</term>
<term>Spectral domain</term>
<term>Subacute vision loss</term>
<term>Tentative diagnosis</term>
<term>Vascular attenuation</term>
<term>Vision loss</term>
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<term>Vitreous opacity</term>
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<front><div type="abstract">Aims To report abnormal fundus hyperautofluorescence (hyper-AF) and loss of outer retinal layers by spectral domain optical coherence tomography in patients with autoimmune retinopathy (AIR). Methods Retrospective, observational case series of 14 eyes of 7 patients diagnosed with an AIR for whom colour fundus photographs, fundus AF images and spectral domain optical coherence tomograms (SD-OCT) were obtained at presentation. Results Seven patients were identified ranging in age from 24 to 73 years. Six had a history of cancer and were diagnosed with cancer associated retinopathy or melanoma associated retinopathy. Among the seven patients, six (86%) had abnormalities by AF or SD-OCT including loss of outer retinal layers in association with hyper-AF. One patient with melanoma associated retinopathy did not have any imaging abnormalities. In one patient with cancer associated retinopathy followed over 8 months, progressive loss of retinal architecture was associated with the formation of a hyper-AF ring. Conclusions Patients with AIR can present with structural abnormalities that are detectable by fundus AF and SD-OCT. The areas of hyper-AF correspond to loss of outer-retinal structures such as the inner segment/outer segment junction, the external limiting membrane and outer nuclear layer. These imaging modalities may be useful in establishing the diagnosis of this rare disease, monitoring disease progression and evaluating response to therapy.</div>
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<region><li>Caroline du Nord</li>
<li>Pennsylvanie</li>
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<name sortKey="Cusick, Michael" sort="Cusick, Michael" uniqKey="Cusick M" first="Michael" last="Cusick">Michael Cusick</name>
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<name sortKey="Mruthyunjaya, Prithvi" sort="Mruthyunjaya, Prithvi" uniqKey="Mruthyunjaya P" first="Prithvi" last="Mruthyunjaya">Prithvi Mruthyunjaya</name>
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